Based on this model, two mathematical equations can be used to predict the microporatio-enhanced transdermal drug flux: the complex primal equation containing a variety of experimentally-determined variables, and the simplified straightforward equation.
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The mathematical model describing drug flux through microporated skin was previously developed. Other works are needed for confirmation and to assess whether such biomarker could be used to predict the response to DMARDs at the individual level. In the present work, the serum concentration of TNF-α was related to further response to DMARDs. Similar results were obtained in the subgroups of patients treated with MTX and patients with early RA of less than 3 years duration. The threshold, which predicted with the best accuracy the response to treatment, was 20.1 pg/ml (sensitivity, specificity, positive and negative predictive values of 75, 78.9, 83.3, and 69.2%, respectively AUC = 80.3%, 95% CI = 62.8-97.7%). The response to therapy was predicted by the baseline serum level of TNF-α (mean = 30.2 pg/ml ± 18 in non-responders vs. ROC curve analyses were performed in order to obtain thresholds allowing the prediction of response.įorty-two patients (mean age = 57 ± 13 years, mean disease duration = 5.4 ± 7.2 years) were included. Potential predictors of response, patients' demographics, disease activity, percentages of PBMC subsets expressing P-gp, serum IL-1β, IL-6, IL-8, IL-10, IL-12, TNF-α levels, were evaluated using univariate and multivariate logistic regression analysis. Response to treatment evaluated at 6 months (ACR20 criteria). INTERVENTION AND FOLLOW-UP: Introduction of one DMARD.
Study design - 6-month follow-up prospective study. To investigate potential predictors of response to conventional DMARDs in RA. As in general population, it is multifactorial in origin and needs careful monitoring and treatment. Nonalcoholic fatty liver disease is very widely prevalent in rheumatoid arthritis patients. In positive cases comorbid like metabolic syndrome was present (71.8%), diabetes mellitus (33.3%), hypertension (59%) FRS score (intermediate to high in (33.3%), history of hakeem/desi medication use (51.3%), while on regression analysis all study parameters except DMARD's had significant association with fatty liver (p<0.05). On next day 10 ml blood was taken by phlebotomist for lipid profile and fasting blood sugar levels, after availability of results 10-years Framingham cardiovascular risk score was calculated.įemales were (81.3%) mean age of (45.4) years, fatty liver was present in n=39 (20.3%). Demographic details were noted, BP, BMI, smoking habits, and waist circumference were noted, then sent to radiology department for ultrasound scan of abdomen by an expert radiologist. One hundred ninety two seropositive rheumatoid arthritis patients were recruited.
This study was conducted from September 1st to March 19, 2019, at Rheumatology OPD, Central Park Medical College Lahore. To determine the frequency of fatty liver (non-alcoholic) disease, Framingham 10-year cardiovascular risk score in rheumatoid arthritis patients.
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